ELK Biotechnology IL-4Rα (phospho Tyr497) rabbit pAb
IL-4Rα (phospho Tyr497) rabbit polyclonal antibody로 IL-4 수용체 알파 사슬의 인산화 부위를 특이적으로 인식. WB, IHC, IF, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며, 세포막 단백질 검출에 적합. 장기 보관은 -20°C에서 가능.
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제품명
IL-4Rα (phospho Tyr497) rabbit pAb
공급업체
ELK Biotechnology
제품 상세 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | IL4R; IL4RA; 582J2.1; Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD antigen CD124 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human IL-4R/CD124 around the phosphorylation site of Tyr497 (AA range: 463–512) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 90 kD |
| GeneID (Human) | 3566 |
| Human Swiss-Prot No | P24394 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; [Isoform 2]: Secreted |
| Species Reactivity | Human; Mouse |
Background
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that binds interleukin 4 and interleukin 13 to regulate IgE production. It also binds IL-4 to promote differentiation of Th2 cells. A soluble form can be produced by proteolysis of the membrane-bound protein, inhibiting IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations are associated with atopy (allergic rhinitis, sinusitis, asthma, eczema) and resistance to HIV-1 infection. Alternate splicing results in multiple transcript variants. (RefSeq, Apr 2012)
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