ELK Biotechnology IL-2Rβ rabbit pAb
IL-2Rβ rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체입니다. IL-2 수용체 베타 서브유닛을 인식하며 WB, IF, ELISA에 적합합니다. 고품질 IgG 항체로 세포막 단백질 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
IL-2Rβ rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | IL2RB; Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; p75; CD antigen CD122 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL-2R beta. AA range: 331-380 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 61 kD |
| GeneID (Human) | 3560 |
| Human Swiss-Prot No | P14784 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in three forms with respect to its ability to bind interleukin 2.
- The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction.
- The intermediate affinity form consists of an alpha/beta subunit heterodimer.
- The high affinity form consists of an alpha/beta/gamma subunit heterotrimer.
Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.
The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
The use of alternative promoters results in multiple transcript variants encoding the same protein, primarily expressed in the hematopoietic system.
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