ELK Biotechnology IL-2Rα (phospho Ser268) rabbit pAb
IL-2Rα (phospho Ser268) rabbit pAb는 인간, 쥐, 마우스 시료에 반응하는 다클론 항체로, WB, IHC, IF, ELISA에 적합합니다. 인산화 Ser268 부위 특이적 인식으로 신호전달 연구에 유용하며, 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
IL-2Rα (phospho Ser268) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | IL2RA; Interleukin-2 receptor subunit alpha; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA; TAC antigen; p55; CD antigen CD25 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications. |
| Immunogen | Synthesized peptide derived from human IL-2R alpha/CD25 around the phosphorylation site of Ser268 (AA range: 223–272) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kDa |
| Gene ID (Human) | 3559 |
| Human Swiss-Prot No. | P01589 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in a low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. [provided by RefSeq, Nov 2009]
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