ELK Biotechnology ApoE rabbit pAb
ApoE rabbit polyclonal antibody for WB, IHC, IF, and ELISA; recognizes human ApoE peptide (AA 37–86); suitable for human, mouse, and rat; 36 kDa band; stored at −20 °C for up to 1 year.
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제품명
ApoE rabbit pAb
제품 개요
ApoE 단백질은 키로미크론의 주요 아포단백질로, 간 및 말초 세포 수용체에 결합하여 중성지방이 풍부한 지질단백질의 정상적인 대사에 필수적입니다. 이 항체는 인간 ApoE 합성 펩타이드(AA 37–86)에 대해 제조된 rabbit polyclonal antibody입니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ApoE rabbit pAb |
| Alternative Names | APOE; Apolipoprotein E; Apo-E |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ApoE (AA range: 37–86) |
| Host | Rabbit |
| Storage | −20 °C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 36 kDa |
| Gene ID (Human) | 348 |
| Human Swiss-Prot No. | P02649 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Secreted; extracellular space and extracellular matrix. In plasma, APOE associates with chylomicrons, remnants, VLDL, LDL, and HDL lipoproteins (PubMed:1911868, 8340399). Lipid-poor oligomeric APOE binds extracellular matrix in a calcium- and heparan-sulfate proteoglycan-dependent manner (PubMed:9488694). Lipidation induces release from the matrix.
배경 (Background)
The APOE gene encodes a major apoprotein of chylomicrons. It binds to liver and peripheral cell receptors and is essential for normal catabolism of triglyceride-rich lipoproteins. The gene is located on chromosome 19 alongside apolipoprotein C1 and C2 genes. Mutations cause familial dysbetalipoproteinemia (Type III hyperlipoproteinemia), resulting in elevated plasma cholesterol and triglycerides due to impaired clearance of chylomicron and VLDL remnants. [RefSeq, Jun 2016]
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