ELK Biotechnology Survivin rabbit pAb(C-ternal)
Survivin 단백질을 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. WB, IHC, IF, ELISA에 적합하며 고감도 검출이 가능합니다. 세포 내 위치 연구 및 세포사멸 억제 관련 연구에 활용됩니다.
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Survivin rabbit pAb (C-ternal)
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Survivin rabbit pAb (C-ternal) |
| Alternative Names | BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Survivin (AA range: 86–135) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 20 kDa |
| Gene ID (Human) | 332 |
| Human Swiss-Prot No. | O15392 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Cytoplasm, nucleus, chromosome, centromere, cytoskeleton (spindle), kinetochore, and midbody.
Localizes at centromeres from prophase to metaphase, spindle midzone during anaphase, and midbody during telophase and cytokinesis.
Accumulates in the nucleus upon treatment with leptomycin B (LMB), an XPO1/CRM1 nuclear export inhibitor.
Colocalizes with AURKB at mitotic chromosomes.
Acetylation at Lys-129 directs localization to the nucleus by enhancing nuclear retention.
Background
This gene belongs to the inhibitor of apoptosis (IAP) family, encoding negative regulatory proteins that prevent apoptotic cell death.
Unlike other IAP family members that contain multiple baculovirus IAP repeat (BIR) domains, this gene encodes a protein with only a single BIR domain and lacks a C-terminal RING finger domain.
Expression is high during fetal development and in most tumors, but low in adult tissues.
Alternatively spliced transcript variants encoding distinct isoforms have been identified.
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