ELK Biotechnology hnRNP K (phospho Ser216) rabbit pAb
hnRNP K (phospho Ser216) rabbit polyclonal antibody for WB and ELISA. Recognizes phosphorylated Ser216 site of human hnRNP K. High specificity and sensitivity for nuclear and cytoplasmic localization studies. Long-term storage at -20°C.
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ELK Biotechnology hnRNP K (phospho Ser216) rabbit pAb
제품 개요
hnRNP K (phospho Ser216) rabbit polyclonal antibody는 인산화된 Ser216 부위를 인식하며, 인간 hnRNP K 단백질을 타겟으로 합니다. Western blot과 ELISA에 적합하며, 세포 내 단백질 위치 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | hnRNP K (phospho Ser216) rabbit pAb |
| Alternative Names | HNRNPK; HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human hnRNP K (phospho Ser216) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 3190 |
| Human Swiss-Prot No | P61978 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, nucleus (nucleoplasm), and cell projection (podosome).
Recruited to p53/TP53-responsive promoters in the presence of functional p53/TP53 (PubMed:16360036).
In case of ASFV infection, localization shifts to predominantly nuclear (PubMed:18775702).
Background
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).
The hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA (hnRNA).
They are associated with pre-mRNAs in the nucleus and influence pre-mRNA processing, mRNA metabolism, and transport.
While most hnRNPs are nuclear, some shuttle between the nucleus and cytoplasm.
The hnRNP K protein contains three KH domains that bind RNA and shows strong affinity for poly(C).
It is implicated in cell cycle progression and exists in several alternatively spliced transcript variants.
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