ELK Biotechnology DREAM (phospho Ser63) rabbit pAb
DREAM (phospho Ser63) rabbit pAb는 인간 Calsenilin/KCNIP3의 Ser63 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA에 적용 가능하며, 세포막·핵·소포체 등 다양한 세포 소기관에서 발현된 단백질 검출에 적합합니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
DREAM (phospho Ser63) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Product name | DREAM (phospho Ser63) rabbit pAb |
| Alternative Names | KCNIP3; CSEN; DREAM; KCHIP3; Calsenilin; A-type potassium channel modulatory protein 3; DRE-antagonist modulator; Kv channel-interacting protein 3; KChIP3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Calsenilin/KCNIP3 around the phosphorylation site of Ser63 (AA range: 29–78) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 29 kD |
| GeneID (Human) | 30818 |
| Human Swiss-Prot No | Q9Y2W7 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm, Cell membrane (Lipid-anchor), Endoplasmic reticulum, Golgi apparatus, Nucleus.
Also membrane-bound, associated with the plasma membrane (PubMed:15485870).
In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.
The sumoylated form is present only in the nucleus.
Background
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, belonging to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium-binding proteins containing EF-hand-like domains. They are integral subunits of native Kv4 channel complexes that regulate A-type currents and neuronal excitability in response to intracellular calcium changes.
The encoded protein also functions as a calcium-regulated transcriptional repressor and interacts with presenilins.
Alternatively spliced transcript variants encoding different isoforms have been described.
[Provided by RefSeq, Jul 2008]
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