ELK Biotechnology Hexb rabbit pAb
HEXB 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, 세포 내 리소좀 및 분비 소낭에 위치한 HEXB 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
Hexb rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HEXB; HCC7; Beta-hexosaminidase subunit beta; Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B; Cervical cancer proto-oncogene 7 protein; HCC-7; N-acetyl-beta-glucosaminidase subunit beta |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HEXB. AA range: 481-530 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 63 kD |
| Gene ID (Human) | 3074 |
| Human Swiss-Prot No. | P07686 |
| Cellular Localization | Lysosome; Cytoplasmic vesicle; Secretory vesicle; Cortical granule |
| Species Reactivity | Human; Rat; Mouse |
Background
Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2 and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both subunits belong to family 20 of glycosyl hydrolases. Mutations in either subunit gene cause accumulation of GM2 ganglioside in neurons, leading to neurodegenerative disorders known as GM2 gangliosidoses. Mutations in the beta subunit gene cause Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, May 2014).
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