ELK Biotechnology HDAC1 (phospho Ser421) rabbit pAb
HDAC1 단백질의 Ser421 인산화 부위를 인식하는 rabbit polyclonal 항체. WB, IHC, IF, ELISA에 사용 가능. 핵 내 HDAC1 단백질 검출용으로 적합. -20°C에서 1년 보관 가능. Human, Mouse, Rat 반응성.
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제품명
HDAC1 (phospho Ser421) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HDAC1; RPD3L1; Histone deacetylase 1; HD1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HDAC1 around the phosphorylation site of Ser421 (AA range: 387-436) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 62 kD |
| Gene ID (Human) | 3065 |
| Human Swiss-Prot No. | Q13547 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/alpha family and is a component of the histone deacetylase complex. It also interacts with the retinoblastoma tumor-suppressor protein, forming a complex that is crucial in controlling cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
[Provided by RefSeq, Jul 2008]
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