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ELK Biotechnology Lck BP-1 (phospho Tyr397) rabbit pAb
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ELK Biotechnology Lck BP-1 (phospho Tyr397) rabbit pAb

상품 한눈에 보기

Human HS1 단백질의 Tyr397 인산화 부위를 인식하는 rabbit polyclonal antibody. WB 및 IHC에 적합하며, 다양한 종(Human, Rat, Mouse)에 반응. 항원 수용체 신호전달 연구 및 세포 분화 관련 단백질 분석에 활용 가능.

판매단위
pk
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ELK Biotechnology ES5723-100UL Lck BP-1 (phospho Tyr397) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES5723-50UL Lck BP-1 (phospho Tyr397) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology Lck BP-1 (phospho Tyr397) rabbit pAb

ELK Biotechnology Lck BP-1 (phospho Tyr397) rabbit pAb

제품 개요

Lck BP-1 (phospho Tyr397) rabbit polyclonal antibody는 인간 HS1 단백질의 인산화 Tyr397 부위를 표적하는 항체로, 항원 수용체 신호전달 및 림프구 기능 연구에 유용합니다.

제품 정보

항목 내용
Product name Lck BP-1 (phospho Tyr397) rabbit pAb
Alternative Names HCLS1; HS1; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75
Applications WB; IHC
Recommended Dilutions WB 1:500–2000; IHC-p 1:50–300
Immunogen Synthesized peptide derived from human HS1 around phosphorylation site of Tyr397 (AA range: 366–415)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 55 kD
GeneID (Human) 3059
Human Swiss-Prot No P14317
Cellular Localization Membrane; Peripheral membrane protein; Cytoplasm; Mitochondrion
Species Reactivity Human; Rat; Mouse

Background

  • Developmental stage: Expressed in early stages of myeloid and erythroid differentiation.
  • Function: Substrate of antigen receptor-coupled tyrosine kinase; plays a role in antigen receptor signaling for clonal expansion and deletion in lymphoid cells; may regulate gene expression.
  • PTM: Phosphorylated by LYN rapidly after cross-linking of surface IgM on B-cells.
  • Similarity: Contains 1 SH3 domain and 4 cortactin repeats.
  • Subunit: Associates with SH2 and SH3 domains of LCK. Binding to LCK SH3 domain occurs constitutively, while SH2 domain binding occurs upon TCR stimulation. Similar binding observed with LYN but not with FYN. Also interacts with HAX1 (C-terminal region) and HS1BP3.
  • Tissue specificity: Expressed only in tissues and cells of hematopoietic origin.

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