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ELK Biotechnology Lck BP-1 (phospho Tyr378) rabbit pAb
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ELK Biotechnology Lck BP-1 (phospho Tyr378) rabbit pAb

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Lck BP-1 (phospho Tyr378) rabbit pAb는 인간, 생쥐, 랫드 시료에 반응하는 다클론 항체로, WB, ELISA, IHC에 적합합니다. 인산화 부위 Tyr378 주변 펩타이드를 면역원으로 하며, 항원 수용체 신호전달 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.

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pk
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ELK Biotechnology ES5722-100UL Lck BP-1 (phospho Tyr378) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES5722-50UL Lck BP-1 (phospho Tyr378) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology Lck BP-1 (phospho Tyr378) rabbit pAb

제품명

Lck BP-1 (phospho Tyr378) rabbit pAb

제품 정보

항목 내용
Alternative Names HCLS1; HS1; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75
Applications WB; ELISA; IHC
Recommended Dilutions WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000
Immunogen Synthesized phospho-peptide around the phosphorylation site of human Lck BP-1 (phospho Tyr378)
Host Rabbit
Storage -20°C, 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 78 kD
Gene ID (Human) 3059
Human Swiss-Prot No. P14317
Cellular Localization Membrane; Peripheral membrane protein; Cytoplasm; Mitochondrion
Species Reactivity Human; Rat; Mouse

Background

  • Developmental stage: Expressed in early stages of myeloid and erythroid differentiation.
  • Function: Substrate of antigen receptor-coupled tyrosine kinase; involved in antigen receptor signaling for clonal expansion and deletion in lymphoid cells; may regulate gene expression.
  • Post-translational modification (PTM): Phosphorylated by LYN rapidly after cross-linking of surface IgM on B-cells.
  • Similarity: Contains one SH3 domain and four cortactin repeats.
  • Subunit: Associates with SH2 and SH3 domains of LCK. Binding to LCK SH3 domain occurs constitutively, while binding to SH2 domain occurs upon TCR stimulation. Shows similar binding with LYN but not with FYN. Directly associates with HAX1 and interacts with HS1BP3.
  • Tissue specificity: Expressed only in tissues and cells of hematopoietic origin.

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