
ELK Biotechnology Granzyme B/H rabbit pAb
Granzyme B/H rabbit pAb는 인간, 마우스, 랫트 반응성을 가진 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 세포 사멸 및 염증 관련 단백질 연구에 적합하며, 고순도 IgG 형태로 -20°C에서 1년 보관 가능.
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Granzyme B/H rabbit pAb
공급업체: ELK Biotechnology
제품 개요
Granzyme B/H rabbit pAb는 인간, 마우스, 랫트에서 반응성을 보이는 폴리클로날 항체로, 세포 사멸 및 면역 반응 연구에 활용됩니다. Granzyme B 단백질은 NK 세포와 CTL에서 분비되어 표적 세포의 아폽토시스를 유도하며, 염증 및 조직 재생 과정에서도 중요한 역할을 합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Granzyme B/H rabbit pAb |
| Alternative Names | GZMB; CGL1; CSPB; CTLA1; GRB; Granzyme B; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMH; C |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/5000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human Granzyme B (AA range: 10–59) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kDa |
| Gene ID (Human) | 2999 |
| Human Swiss-Prot No | P10144 / P20718 |
| Cellular Localization | Secreted; Cytolytic granule; Delivered into target cell by perforin (PubMed:20038786) |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis.
[Provided by RefSeq, Sep 2016]
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