ELK Biotechnology Rac GAP1 (phospho Ser387) rabbit pAb

Rac GAP1 (phospho Ser387) rabbit pAb

제품 개요

Rac GAP1 (phospho Ser387) rabbit polyclonal antibody는 인간 GTPase Activating Protein의 Ser387 인산화 부위를 기반으로 제작된 항체로, 세포 분열 및 미세소관 관련 단백질 연구에 유용합니다.

제품 정보

세포 내 위치

• Nucleus, Cytoplasm, Cytoskeleton (spindle)
• Cytoplasmic vesicle, secretory vesicle, acrosome
• Cleavage furrow, Midbody, Midbody ring
• Cell membrane (peripheral membrane protein; cytoplasmic side)
• Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and acrosome
• During interphase, localized to nucleus and cytoplasm along microtubules
• Redistributed to central spindle (anaphase), midbody ring (telophase/cytokinesis)
• Colocalizes with RHOA at myosin contractile ring during cytokinesis
• Colocalizes with ECT2 to mitotic spindles, cleavage furrow, and midbody
• Colocalizes with Cdc42 to spindle microtubules

Background

This gene encodes a GTPase-activating protein (GAP) that is a component of the centralspindlin complex. It binds activated forms of Rho GTPases and stimulates GTP hydrolysis, leading to negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been identified, and a pseudogene exists on chromosome 12 (RefSeq, Feb 2016).