ELK Biotechnology GRF-1 (phospho Tyr1105) rabbit pAb
GRF-1 (phospho Tyr1105) rabbit pAb는 인산화 Tyr1105 부위를 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 사람, 마우스, 랫트 시료에 반응하며 세포막 및 세포골격 관련 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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GRF-1 (phospho Tyr1105) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | GRF-1 (phospho Tyr1105) rabbit pAb |
| Alternative Names | ARHGAP35; GRF1; GRLF1; KIAA1722; Rho GTPase-activating protein 35; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human GRF-1 around the phosphorylation site of Tyr1105 (AA range: 1071–1120) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160 kDa |
| Gene ID (Human) | 2909 |
| Human Swiss-Prot No. | Q9NRY4 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cytoskeleton, cilium basal body, nucleus, and cell membrane. In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to plasma membrane ruffling regions where it colocalizes with polymerized actin. |
Background
The human glucocorticoid receptor DNA-binding factor associates with the promoter region of the glucocorticoid receptor gene (hGR gene) and acts as a repressor of glucocorticoid receptor transcription. The deduced amino acid sequence shows three zinc finger motifs and one leucine zipper-like motif where one cysteine replaces leucine. GRLF1 enhances homologous down-regulation of wild-type hGR expression. Biochemical analysis suggests that GRLF1 interaction is sequence-specific and that transcriptional efficacy is regulated through its interaction with specific sequence motifs. Expression levels are regulated by glucocorticoids. (RefSeq, Jul 2008)
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