ELK Biotechnology GRF-1 (phospho Tyr1087) rabbit pAb
GRF-1 (phospho Tyr1087) rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 폴리클로날 항체입니다. Western blot과 ELISA에 적합하며, 세포질 및 세포막 부위의 인산화된 GRF-1 단백질 검출에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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GRF-1 (phospho Tyr1087) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | GRF-1 (phospho Tyr1087) rabbit pAb |
| Alternative Names | ARHGAP35; GRF1; GRLF1; KIAA1722; Rho GTPase-activating protein 35; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human GRF-1 (phospho Tyr1087) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 190 kD |
| Gene ID (Human) | 2909 |
| Human Swiss-Prot No. | Q9NRY4 |
| Cellular Localization | Cytoplasm, cytoskeleton, cilium basal body, nucleus, and cell membrane. In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin. |
| Species Reactivity | Human; Mouse; Rat |
Background
The human glucocorticoid receptor DNA binding factor associates with the promoter region of the glucocorticoid receptor gene (hGR gene) and acts as a repressor of glucocorticoid receptor transcription. The deduced amino acid sequence shows three zinc finger motifs and one leucine zipper-like motif in which one cysteine replaces leucine. GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence-specific and that its transcriptional efficacy is regulated through interaction with specific sequence motifs. Expression levels are regulated by glucocorticoids.
[Provided by RefSeq, Jul 2008]
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