ELK Biotechnology GR (phospho Ser203) rabbit pAb

제품명

GR (phospho Ser203) rabbit pAb

제품 정보

세포 내 위치

• Isoform Alpha: Cytoplasm, Nucleus, Mitochondrion, Cytoskeleton (spindle, centrosome). After ligand activation, translocates from cytoplasm to nucleus. Shows time-dependent localization with NR1D1.
• Isoform Beta: Predominantly nuclear, with some cytoplasmic expression.
• Isoform Alpha-B: Cytoplasm and nucleus; translocates to nucleus upon ligand activation.

Background

This gene encodes the glucocorticoid receptor (GR), which functions both as a transcription factor binding to glucocorticoid response elements in target gene promoters and as a regulator of other transcription factors. Normally located in the cytoplasm, the receptor translocates to the nucleus upon ligand binding. It plays key roles in inflammatory response, cell proliferation, and differentiation. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing and multiple translation initiation sites result in several functional isoforms with diverse cytoplasm-to-nucleus trafficking patterns.