ELK Biotechnology NMDAε2 (phospho Tyr1336) rabbit pAb
NMDA 수용체의 인산화 형태(Tyr1336)를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫드 반응성. 장기 기억 및 시냅스 전달 연구에 적합. -20°C에서 1년 보관.
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제품명
NMDAε2 (phospho Tyr1336) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NMDAR2B around the phosphorylation site of Tyr1336 (AA range: 1302–1351) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kDa |
| Gene ID (Human) | 2904 |
| Human Swiss-Prot No. | Q13224 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Cell junction, synapse, postsynaptic cell membrane; Late endosome; Lysosome; Cytoplasm, cytoskeleton; Co-localizes with motor protein KIF17 along microtubules |
| Species Reactivity | Human; Mouse; Rat |
Background
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channels are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These channels are heteromers composed of three subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D), and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. (RefSeq, Jul 2008)
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