ELK Biotechnology NMDAε1/2 rabbit pAb
NMDAε1/2 rabbit pAb는 인간, 마우스, 랫트에서 NMDA 수용체 서브유닛 2A/2B를 인식하는 고품질 폴리클로날 항체입니다. IHC, IF, ELISA에 적합하며 고감도 검출을 제공합니다. 장기 기억 및 시냅스 신호 연구에 활용됩니다.
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제품명
NMDAε1/2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human NMDAR2A/B (AA range: 1216–1265) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 2903 / 2904 |
| Human Swiss-Prot No. | Q12879 / Q13224 |
| Cellular Localization | Cell projection, dendritic spine; Cell membrane (multi-pass membrane protein); Cell junction, synapse; Postsynaptic cell membrane; Cytoplasmic vesicle membrane. Expression at dendrite cell membrane and synapses is regulated by SORCS2 and the retromer complex. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which triggers several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. (RefSeq, May 2014)
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