ELK Biotechnology GluR-1 (phospho Ser849) rabbit pAb
GluR-1 (phospho Ser849) rabbit pAb는 인간 GluR1 단백질의 Ser849 인산화 부위를 인식하는 고품질 폴리클로날 항체입니다. IHC, IF, ELISA에 사용 가능하며, 신경세포 내 흥분성 글루탐산 수용체 연구에 적합합니다. -20°C에서 1년 보관 가능합니다.
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제품명
GluR-1 (phospho Ser849) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
GluR-1 (phospho Ser849) rabbit pAb는 인간 GluR1 단백질의 Ser849 인산화 부위를 인식하도록 제작된 폴리클로날 항체입니다. 신경세포 내 글루탐산 수용체의 발현 및 위치 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GRIA1; GLUH1; GLUR1; Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic; AMPA 1; GluA1 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human GluR1 around the phosphorylation site of Ser849 (AA range: 816–865) |
| Species Reactivity | Human; Mouse; Rat |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 2890 |
| Human Swiss-Prot No | P42261 |
세포 내 위치 (Cellular Localization)
- Cell membrane; Multi-pass membrane protein
- Endoplasmic reticulum membrane; Multi-pass membrane protein
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
- Postsynaptic density membrane; Multi-pass membrane protein
- Cell projection, dendrite; dendritic spine
- Early endosome membrane; recycling endosome membrane
- Presynapse and synapse regions
- Interaction with CACNG2, CNIH2, CNIH3 promotes surface expression
- Colocalizes with PDLIM4 in early endosomes
- Somatodendritic localization, excluded from axons
- Localized to cone photoreceptor pedicles (By similarity)
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes. These receptors form heteromeric protein complexes with multiple transmembrane subunits, functioning as ligand-gated ion channels. Classification of glutamate receptors is based on activation by different pharmacologic agonists. This gene belongs to the AMPA receptor family (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate). Alternatively spliced transcript variants encoding different isoforms have been identified.
[provided by RefSeq, Jul 2008]
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