ELK Biotechnology GluR-1 (phospho Ser863) rabbit pAb
인간 GluR1 단백질의 Ser863 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 적합하며 고특이성과 재현성을 제공. 신경세포 내 흥분성 글루탐산 수용체 연구에 활용 가능.
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GluR-1 (phospho Ser863) rabbit pAb
공급업체: ELK Biotechnology
제품명: GluR-1 (phospho Ser863) rabbit polyclonal antibody
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GRIA1; GLUH1; GLUR1; Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic; AMPA 1; GluA1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human GluR1 around the phosphorylation site of Ser863 (AA range: 829–878) |
| Host | Rabbit |
| Storage | -20°C (1 year) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 102 kD |
| Gene ID (Human) | 2890 |
| Human Swiss-Prot No | P42261 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Cell membrane; Multi-pass membrane protein
- Endoplasmic reticulum membrane; Multi-pass membrane protein
- Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
- Cell junction, synapse, postsynaptic density membrane; Multi-pass membrane protein
- Cell projection, dendrite; dendritic spine
- Early endosome membrane; Recycling endosome membrane
- Cell junction, synapse, presynapse
- Interaction with CACNG2, CNIH2, and CNIH3 promotes cell surface expression
- Colocalizes with PDLIM4 in early endosomes
- Displays somatodendritic localization and is excluded from axons in neurons (By similarity)
- Localized to cone photoreceptor pedicles (By similarity)
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions that form ligand-gated ion channels. The classification of glutamate receptors is based on activation by different pharmacologic agonists. This gene belongs to the AMPA receptor family (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate). Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [RefSeq, Jul 2008]
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