ELK Biotechnology GPS2 rabbit pAb
GPS2 단백질을 인식하는 토끼 폴리클로날 항체로 WB와 ELISA에 사용 가능. 인간 유래 합성 펩타이드 항원으로 제작되었으며, 핵·미토콘드리아·세포질에 위치한 GPS2 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
GPS2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GPS2; G protein pathway suppressor 2; GPS-2 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPS2 (AA range: 11–60) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kD |
| Gene ID (Human) | 2874 |
| Human Swiss-Prot No. | Q13227 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Mitochondrion, Cytoplasm (cytosol). Sumoylation regulates subcellular location (PubMed:24943844). Relocates from mitochondria to nucleus following desumoylation, mediating mitochondrial stress response (By similarity). |
Background
This gene encodes a protein involved in G protein–mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene can potently suppress RAS- and MAPK-mediated signals and interfere with JNK activity, suggesting a role in signal repression. The encoded protein is an integral subunit of the NCOR1–HDAC3 (nuclear receptor corepressor 1–histone deacetylase 3) complex, which inhibits JNK activation through this subunit and may provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [Provided by RefSeq, Jul 2008]
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