ELK Biotechnology PA26 rabbit pAb
SESN1 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. p53 관련 산화스트레스 반응 연구에 적합. 사람, 마우스, 랫트 반응성. 핵 및 세포질에 발현되는 Sestrin-1 검출용.
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제품명
PA26 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/20000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human SESN1 (AA 271–320) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 57 kDa |
| Gene ID (Human) | 27244 |
| Human Swiss-Prot No. | Q9Y6P5 |
| Cellular Localization | Nucleus, Cytoplasm |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, resulting in inhibition of the mammalian target of rapamycin (mTOR) protein. It also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and its expression is a potential marker for radiation exposure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (RefSeq, Dec 2010)
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