ELK Biotechnology p52 S6 kinase rabbit pAb

ELK Biotechnology p52 S6 kinase rabbit pAb

제품 개요

p52 S6 kinase rabbit polyclonal antibody는 인간 RPS6KC1 유래 합성 펩타이드를 면역원으로 하여 제작된 항체입니다. S6 kinase subfamily에 속하며 sphingosine-1 phosphate(SPP) 신호전달에 관여하는 단백질 연구용으로 적합합니다.

제품 정보

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Caution: Arg-820 found instead of Lys-820 at binding site
• Domain: First kinase domain is pseudokinase lacking ATP-binding and active sites
• Function: May transmit sphingosine-1 phosphate (SPP)-mediated signaling
• Similarity: Belongs to protein kinase superfamily; Ser/Thr protein kinase family; S6 kinase subfamily
• Contains: 1 MIT domain, 1 PX domain, 2 protein kinase domains
• Subcellular location: Also found in small dot-like or ring-shaped early endosome structures
• Subunit interaction: Interacts with SPHK1 and phosphatidylinositol 3-phosphate
• Tissue specificity: Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney, and liver; weakly expressed in thymus, small intestine, lung, and colon