ELK Biotechnology Nephrocystin-4 rabbit pAb
Nephrocystin-4 단백질을 인식하는 rabbit polyclonal antibody로, 인체·흰쥐·생쥐 시료에 반응합니다. IHC, IF, ELISA에 사용 가능하며, 세포 내 세포골격 및 섬모 기저체에 주로 위치합니다. 신장 기능 및 Nephronophthisis 관련 연구에 적합합니다.
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제품명
Nephrocystin-4 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | NPHP4; KIAA0673; Nephrocystin-4; Nephroretinin |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NPHP4 (AA range: 877–926) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 261734 |
| Human Swiss-Prot No | O75161 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치
Cytoplasm, cytoskeleton, cilium basal body.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Cell junction, tight junction.
Nucleus.
In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions (By similarity).
Localizes to the ciliary transition zone (By similarity).
In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity).
배경 정보
This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin and belongs to a multifunctional complex localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Apr 2014]
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