Thermo Fisher Scientific GALNT4 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
IRFNSVTELCA EVPEQKNYVG MQNCPKDGFP VPANIIWHFK EDGTIFHPHS GLCLSAYRTP EGRPDVQMRT CDA

Highest antigen sequence identity to the following orthologs:

• Mouse: 86%
• Rat: 38%

Target Information

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes.
GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins.

They are characterized by:

• N-terminal transmembrane domain
• Stem region
• Lumenal catalytic domain containing GT1 motif and Gal/GalNAc transferase motif
• C-terminal ricin/lectin-like domain

GalNAc-Ts have different but overlapping substrate specificities and expression patterns.
In vitro, the encoded protein can complement other GalNAc-Ts in complete O-glycosylation of mucin-1 tandem repeat and can O-glycosylate the P-selectin glycoprotein ligand-1 molecule.
The coding region of this gene is contained within a single exon.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.