Thermo Fisher Scientific HnRNP Q Polyclonal Antibody
HnRNP Q 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC(P), ICC/IF에 적합하며 인간 시료에 반응. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HnRNP Q. Recombinant protein control fragment (Product #RP-98834). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642499 |
Product Specific Information
Immunogen sequence:
GNGTEEPMDT TSAVIHSENF QTLLDAG
Antigen sequence identity:
Mouse – 100%, Rat – 100%
Target Information
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q is implicated in mRNA processing mechanisms. It is a component of the CRD-mediated complex that promotes MYC mRNA stability. Isoforms 1, 2, and 3 associate with pre-mRNA, splicing intermediates, and mature mRNA complexes. Isoform 1 binds to apoB mRNA AU-rich sequences and participates in the APOB mRNA editosome complex, potentially modulating post-transcriptional C-to-U RNA editing via interactions with A1CF or APOBEC1. It may also be involved in translationally coupled mRNA turnover and in cytoplasmic mRNA decay mechanisms. Isoform 3 may contribute to vesicle-based mRNA transport. Additionally, hnRNP Q is a component of the GAIT complex, which mediates interferon-gamma-induced transcript-selective translation inhibition during inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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