Thermo Fisher Scientific TNIP3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

Immunogen sequence:
NKEKEHYECE IKRLNKALQD ALNIKCSFSE DCLRKSRVEF CHEEMRTEME VLKQQVQIYE EDFKKERSDR ERLNQEKEEL QQINETSQSQ LNR

• Highest antigen sequence identity to orthologs:
  • Mouse: 46%
  • Rat: 46%

Target Information

The nuclear factor NF-kappa-B plays key roles in development and immunity.
ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a negative feedback regulator of LPS-induced NF-kappa-B activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS.

Expression profile:

• High: brain, thymus, lymph node, lung, fetal liver
• Low: kidney, bone marrow

ABIN3 interacts with A20 to interfere with TRAF2-mediated transactivation signals. It is induced by Listeria infection and slightly downregulated by dexamethasone. Enhanced expression in monocytes is associated with sepsis.
ABIN3 is an IL-10-induced gene product that attenuates NF-kappa-B in human macrophages but is inactive in mice, representing species-specific IL-10 response differences.
At least four isoforms of ABIN3 are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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