Thermo Fisher Scientific TNIP3 Polyclonal Antibody
Human TNIP3 단백질에 특이적인 Rabbit Polyclonal Antibody로, Western Blot 및 Immunohistochemistry(Paraffin)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer(40% glycerol 포함)에 보관됩니다. NF-kappa-B 활성 억제 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TNIP3. Recombinant protein control fragment (Product #RP-100182). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648785 |
Product Specific Information
Immunogen sequence:
NKEKEHYECE IKRLNKALQD ALNIKCSFSE DCLRKSRVEF CHEEMRTEME VLKQQVQIYE EDFKKERSDR ERLNQEKEEL QQINETSQSQ LNR
- Highest antigen sequence identity to orthologs:
- Mouse: 46%
- Rat: 46%
Target Information
The nuclear factor NF-kappa-B plays key roles in development and immunity.
ABIN3 (A20-binding inhibitor of NF-kappa-B activation 3), also known as TNFAIP3-interacting protein 3 (TNIP3), is a negative feedback regulator of LPS-induced NF-kappa-B activation. ABIN3 is a 39 kDa protein that negatively regulates NF-kappa-B activation in response to TNF and LPS.
Expression profile:
- High: brain, thymus, lymph node, lung, fetal liver
- Low: kidney, bone marrow
ABIN3 interacts with A20 to interfere with TRAF2-mediated transactivation signals. It is induced by Listeria infection and slightly downregulated by dexamethasone. Enhanced expression in monocytes is associated with sepsis.
ABIN3 is an IL-10-induced gene product that attenuates NF-kappa-B in human macrophages but is inactive in mice, representing species-specific IL-10 response differences.
At least four isoforms of ABIN3 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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