Thermo Fisher Scientific Cry1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Various biochemical, physiological, and behavioral processes display circadian rhythms controlled by an internal biological clock. The central mechanisms driving this clock involve an autoregulatory transcription/post-translation-based feedback loop. Cryptochrome 1 (CRY1) and Cryptochrome 2 (CRY2) are DNA-binding flavoproteins homologous to blue-light receptors and photolyases.
In Drosophila, CRY functions as a photoreceptor for the circadian clock, binding to the clock component TIM in a light-dependent manner and blocking its function. Mammalian CRY1 and CRY2 act via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They regulate circadian rhythms by modulating Per1 transcriptional cycling through interactions with both activators and feedback inhibitors.
Mutant mice lacking Cry1 or Cry2 show altered periodicity of locomotor activity, highlighting their essential roles in synchronizing circadian phases. The absence of both proteins results in arrhythmicity, demonstrating the necessity of Cry1 and Cry2 balance for proper clock function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.