Thermo Fisher Scientific SAV1 Monoclonal Antibody (3B2)
SAV1 단백질을 인식하는 Mouse monoclonal antibody (Clone 3B2). Western blot, ICC/IF, ELISA, IP 등 다양한 응용 가능. Human 반응성, 비결합형 액상 형태, PBS buffer에 보관. Hippo signaling 연구용으로 적합.
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Thermo Fisher Scientific SAV1 Monoclonal Antibody (3B2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 60 µg/mL |
| ELISA | 0.1 ng/mL |
| Immunoprecipitation (IP) | 1–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B2 |
| Immunogen | SAV1 (NP_068590, 300–383 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
HTAEIPDWLQ VYARAPVKYD HILKWELFQL ADLDTYQGML KLLFMKELEQ IVKMYEAYRQ ALLTELENRK QRQQWYAQQH GKNF
Target Information
Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylate and activate LATS1/2 with MOB1. This leads to phosphorylation and inactivation of YAP1 and WWTR1/TAZ, preventing their nuclear translocation and regulating genes involved in cell proliferation, death, and migration.
SAV1 is essential for STK3/MST2 and STK4/MST1 activation, promoting cell-cycle exit and terminal differentiation in developing epithelial tissues. It also regulates centrosome disjunction by controlling NEK2 localization and phosphorylation of CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates ESR1 transcriptional activity via phosphorylation modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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