Thermo Fisher Scientific Ion GeneStudio S5 Prime System for Agrigenomics

Ion GeneStudio™ S5 Prime System for Agrigenomics

The Ion GeneStudio S5 Prime System is a semiconductor-based next-generation sequencing (NGS) system that enables simple, targeted sequencing workflows. It is ideal for core and service labs requiring maximum throughput and rapid turnaround from a benchtop NGS system. The system offers unparalleled breadth and depth, from large panels or exomes to clinical oncology research focused on low allele frequency applications.

With cartridge-based reagents, the system is simple to use and provides scalability and flexibility. It uses Ion 5 Series chips to support a broad range of high-throughput sequencing for clinical research and various applications, from microbial genomes and gene panels to exomes and transcriptomes.

Key Features

• Select the appropriate Ion 5 Series chip (Ion 510–550) to achieve 2–130 million reads per run
• Reduce setup time and complexity with cartridge-based plug-and-play reagents
• Complete sequencing run and analysis within hours

The Ion GeneStudio S5 Series

The Ion GeneStudio S5 Series sequencers share the same foundational technology and fluidic architecture across all three instruments:

• Ion GeneStudio S5 System
• Ion GeneStudio S5 Plus System
• Ion GeneStudio S5 Prime System

The primary difference among these instruments lies in on-sequencer analysis time.

Speed

Leveraging the speed of semiconductor sequencing, the Ion GeneStudio S5 Series produces high-quality sequencing data in just a few hours. When paired with the Ion Chef System, users can go from DNA library to data in as little as 24 hours with only 45 minutes of total hands-on time.

Simplicity

With single-day installation, a user-friendly interface, and cartridge-based reagents, the Ion GeneStudio S5 Series is easy to operate. Combined with:

• Ion AmpliSeq technology for target selection
• Ion Chef System for automated library and template preparation
• Ion Reporter Software for automated variant annotation

Targeted sequencing is simpler than ever.

Small Sample Input

Low-input DNA from challenging sample types such as FFPE tissue, fine needle aspirates, and cfDNA from blood can be sequenced using as little as 1 ng of DNA or RNA, thanks to Ion AmpliSeq technology and the Ion GeneStudio S5 Series.

Scalability

The Ion 5 Series chips provide multiple throughput options, allowing scalability from small to large projects. This flexibility enables multiple targeted sequencing or microbial applications on a single system—no need for multiple instruments.

Simple Analysis and Storage Solutions

• Torrent Suite Software: Pre-installed on the Torrent Server for planning, monitoring, and analyzing runs.
• Ion Reporter Software: Cloud or local options for variant annotation, integration, and interpretation.

Services and Support

Thermo Fisher Scientific provides extensive global support with over 2,000 field personnel, including Application Specialists and Service Engineers.

Available Support Plans and Services:

• Service and support plans: Maximize instrument performance and uptime
• Qualification services: Ensure installation and operation per manufacturer specifications
• Training: Courses on experimental design, data analysis, troubleshooting, and operation
• Bioinformatics support: Tailored NGS informatics and data analysis assistance
• DataSafe Solution: Comprehensive lab data storage and backup solutions

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