Thermo Fisher Scientific FAS (CD95) Polyclonal Antibody
Thermo Fisher Scientific의 FAS (CD95) Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 FAS 단백질을 검출하는 고품질 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human FAS (Accession P25445), amino acid residues I295–V335 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899850 |
Product Specific Information
Antibody detects endogenous levels of total FAS.
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor of the TNFR superfamily. It also exists in a soluble form (~26 kDa). Activation of FAS leads to aggregation of intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases, triggering apoptosis.
FAS can activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and participates in proliferative signaling in fibroblasts and T cells. Multiple spliced transcript variants encode distinct isoforms, with soluble forms potentially regulating apoptosis negatively.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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