Thermo Fisher Scientific CFHR5 Polyclonal Antibody
CFHR5 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 Affinity Chromatography 정제 제품입니다. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 450–569 of human CFHR5 (NP_1104141) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.93 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804453 |
Product Specific Information
Immunogen sequence:
GPPPSINNGD TTSFPLSVYP PGSTVTYRCQ SFYKLQGSVT VTCRNKQWSE PPRCLDPCVV SEENMNKNNI QLKWRNDGKL YAKTGDAVEF QCKFPHKAMI SSPPFRAICQ EGKFEYPICE
Positive Samples:
HepG2, K-562, Mouse liver, Rat liver
Target Information
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs: the first two repeats have heparin binding properties, repeats 5–7 have heparin and C-reactive protein binding properties, and the C-terminal repeats are similar to a complement component 3b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated (but not causally linked) with membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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