Thermo Fisher Scientific ABC2 Polyclonal Antibody
Thermo Fisher Scientific의 ABC2 Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Rabbit IgG로 제작된 다클론 항체입니다. Western blot, IHC, ICC, ELISA 등 다양한 실험에 활용 가능하며 KLH 결합 합성 펩타이드(aa 721–820)를 면역원으로 사용했습니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ABC2, amino acids 721–820 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Recruited by release factors to stalled ribosomes with SMG1 and SMG9 (forming the SMG1C protein kinase complex). In the SMG1C complex, it mediates recruitment of SMG1 to the ribosome:SURF complex and suppresses SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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