Thermo Fisher Scientific EMR4 Polyclonal Antibody
Rabbit polyclonal antibody against human EMR4 protein. Validated for Western blot (1:500–1:1,000). Unconjugated, liquid form, 1 mg/mL concentration. Suitable for research use only, stored at -20°C and shipped on wet ice.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from the internal region of human EMR4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556167 |
Target Information
FIRE is a 689 amino acid protein that maps to human gene EMR4. It is also known as EGF-like module-containing mucin-like hormone receptor-like 4 and belongs to the G protein-coupled receptor 2 (LN-TM7) subfamily.
The EGF-TM7 family comprises proteins with EGF-like domains at their extracellular N-terminus coupled to a classical seven-transmembrane (TM7) cassette. FIRE is believed to mediate cellular interactions between myeloid cells and beta cells.
FIRE is a membrane-bound, multi-pass protein that is proteolytically cleaved into two subunits:
- An extracellular alpha subunit
- A seven-transmembrane subunit
It contains one GPS (G protein-coupled receptor proteolytic cleavage site) domain and two EGF (epidermal growth factor)-like domains, the second of which mediates interaction with its putative ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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