Thermo Fisher Scientific BUB1B Monoclonal Antibody (OTI10B7), TrueMAB
인간 BUB1B 단백질을 인식하는 마우스 모노클로날 항체로서 WB, IHC, ICC/IF에 사용 가능. 고순도 친화 크로마토그래피 정제 제품으로 안정적인 액상 형태. 세포 분열 체크포인트 연구 및 암 관련 단백질 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI10B7 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human BUB1B expression vector |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BUBR1 is a member of the Ser/Thr protein kinase family and acts as a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. Defects in spindle checkpoints contribute to genetic instability and may lead to malignant transformation. Human cells contain two related checkpoint protein kinases, hBUBR1 and hBUB1, both derived from the BUB1 gene. These kinases monitor mitotic kinetochore-microtubule interactions and are essential for normal mitotic progression. BUBR1 has been detected in various human cancers and identified as a binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which may promote breast cancer progression by compromising mitotic checkpoint control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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