Thermo Fisher Scientific NRXN3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NRXN3.

Target Information

Neurexins comprise a family of neuronal cell surface proteins, including neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3), and Caspr (neurexin IV). Neurexins I–III are expressed as α and β isoforms.

• The α isoforms contain three cassettes with two LNS (Laminin A, Neurexins, Sex hormone-binding) domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal.
• The α isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin α-latrotoxin.
• The β isoforms have only one LNS domain, bind to neuroligins, and play a role in the formation and remodeling of synapses.

Caspr (Contactin-Associated Protein 1, also known as Paranodin in mouse) contains an extracellular domain similar to the other neurexins and binds to the surface glycoprotein Contactin. Caspr and Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), define distinct subdomains in myelinated axons. Caspr localizes at paranodal junctions, while Caspr2 colocalizes with Shaker-like K⁺ channels in the juxtaparanodal region. Caspr may play a role in glial-neuronal communication during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.