Thermo Fisher Scientific PIMT Polyclonal Antibody
PIMT 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, IP 등 다양한 응용에 적합. 고순도 액상 형태(1 mg/mL)로 제공되며, 4°C 보관 및 Wet ice 배송. 인체 PRIP-Interacting Protein with Methyltransferase Domain(803-853 aa) 유래 면역원 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 803–853 of Human PRIP-Interacting Protein with Methyltransferase Domain |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with Tris-EDTA (pH 9.0) is recommended for FFPE tissue sections.
Target Information
Catalyzes the two serial methylation steps for conversion of 7-monomethylguanosine (m⁷G) caps of snRNAs and snoRNAs to 2,2,7-trimethylguanosine (m²,²,⁷G) cap structures. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m⁷G cap of U snRNAs leads to their concentration in nuclear foci, colocalization with coilin, and formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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