Thermo Fisher Scientific BICD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human BICD1 protein. Validated for WB and IHC applications. High antigen sequence identity with mouse and rat. Purified by antigen affinity chromatography and supplied as a liquid unconjugated form. Suitable for res...
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human BICD1 (Product #RP-97780) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638552 |
Product Specific Information
Immunogen sequence:
YRQSRVTRSG SLKGPDDPRG LLSPRLARRG VSSPVETRTS SEPVAKESTE ASKEPSPTKT PTISPVITAP PSSPVLDTSD IRKE
Antigen sequence identity:
- Mouse: 94%
- Rat: 94%
Target Information
BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.
BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting that BICD1 regulates COPI-independent Golgi-ER transport.
BICD1 also interacts with Rab6B, a Rab6 isoform primarily expressed in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in Rab6B-regulated retrograde cargo transport in neuronal cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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