Thermo Fisher Scientific BICD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
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Product Specifications

Product Specific Information

Immunogen sequence:
YRQSRVTRSG SLKGPDDPRG LLSPRLARRG VSSPVETRTS SEPVAKESTE ASKEPSPTKT PTISPVITAP PSSPVLDTSD IRKE

Antigen sequence identity:

• Mouse: 94%
• Rat: 94%

Target Information

BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.
BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting that BICD1 regulates COPI-independent Golgi-ER transport.
BICD1 also interacts with Rab6B, a Rab6 isoform primarily expressed in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in Rab6B-regulated retrograde cargo transport in neuronal cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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