Thermo Fisher Scientific FAM21C Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting.
Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC.
Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex, promoting localized F-actin polymerization needed for vesicle scission.
Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2).
Involved in endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins such as GLUT1.
Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35, and for the endosomal recruitment of CCC and retriever complexes subunits COMMD1, CCDC93, and VPS35L.
[UniProt]

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.