Thermo Fisher Scientific Phospho-ICAM-3 (Ser518) Polyclonal Antibody
인간 CD50/ICAM-3의 Ser518 인산화 부위에 특이적인 폴리클로날 항체. Western blot에 적합하며, 면역세포 활성화 및 접착 관련 연구에 활용 가능. Rabbit IgG 형식, 비결합형, 액상 형태로 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human CD50/ICAM-3 around the phosphorylation site of Ser518 (S-G-SP-Y-H) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555051 |
Target Information
CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
Besides functioning as an adhesive molecule mediating contact between T cells and antigen-presenting cells, ICAM-3 regulates the affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation.
ICAM-3 plays an essential role in the initiation of the immune response on both T cells and antigen-presenting cells and also interacts with CD209 (DC-SIGN), a C-type lectin of dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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