Thermo Fisher Scientific Nectin 3 Monoclonal Antibody (6D5B2)
Thermo Fisher Scientific의 Nectin 3 단클론 항체(6D5B2)는 인간 Nectin-3 단백질을 특이적으로 인식합니다. Western blot, Flow cytometry, ELISA에 적합하며, Protein G로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D5B2 |
| Immunogen | Purified recombinant fragment of human CD113 (AA: extra 282–404) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090736 |
Target Information
Nectin-3 is an 83 kDa type I transmembrane glycoprotein belonging to the immunoglobulin supergene family. It functions as a calcium-independent cell-cell adhesion molecule and is part of the nectin family (nectin-1 to nectin-4). Nectins mediate homophilic and heterophilic interactions forming various cell junctions, including adherens junctions, synaptic junctions, and Sertoli cell-spermatid junctions.
Nectin-3 (also known as PRR3) is predominantly expressed in testis and placental tissues, as well as in many cell lines. It interacts with afadin, an actin-binding protein, at cadherin-based cell-cell junctions. The ectodomains of nectin-3 and CD155 (Poliovirus Receptor) exhibit strong binding affinity. Experimental disruption of nectin-3 interactions can affect Sertoli cell structure and spermatid adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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