Thermo Fisher Scientific Angiotensin II/III Monoclonal Antibody (Ang II E7)

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunocytochemistry (ICC/IF)

1:200

-

ELISA (ELISA)

1:50-1:200

-

Product Specifications

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

Ang II E7

Immunogen

Peptide sequence [DRVYIHPF] corresponding to angiotensin II, conjugated to a proprietary molecular weight carrier. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Angiotensin II/III,uniProtId:P01019-1,ncbiNodeId:9606,antigenRange:34-41,antigenLength:485,antigenImageFileName:MA1-82996_Angiotensin_IIIII_P01019-1_House_mouse.svg,antigenImageFileNamePDP:MA1-82996_Angiotensin_IIIII_P01019-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_927005

Product Specific Information

Predicted to react with horse, pig, rat and sheep based on sequence homology.

Mouse anti Human angiotensinogen II antibody, clone 13/96/Ang E7 reacts with Angiotensin II and III.Negligible reactivity was observed with Angiotensin I or Angiotensinogen.

Target Information

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Angiotensin III is formed after a terminal aspartic acid amino acid group is cleaved by aminopeptidase A. Angiotensin III has decreased effect on blood pressure, but maintains angiotensin II`s hormonal effects. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.