Thermo Fisher Scientific Angiotensin II/III Monoclonal Antibody (Ang II E7)
Angiotensin II/III 단클론 항체(Ang II E7)는 Western blot, ICC/IF, ELISA에 사용 가능하며, 인간 Angiotensin II 및 III에 특이적으로 반응합니다. 서열 상 유사성에 따라 말, 돼지, 쥐, 양에서도 반응이 예측됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA182996
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Angiotensin II/III Monoclonal Antibody (Ang II E7)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:200 |
| ELISA | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Ang II E7 |
| Immunogen | Peptide sequence [DRVYIHPF] corresponding to angiotensin II, conjugated to a proprietary molecular weight carrier |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_927005 |
Product Specific Information
- Predicted to react with horse, pig, rat, and sheep based on sequence homology.
- Mouse anti-human angiotensinogen II antibody, clone 13/96/Ang E7 reacts with Angiotensin II and III.
- Negligible reactivity was observed with Angiotensin I or Angiotensinogen.
Target Information
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II.
Angiotensin II is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.
Angiotensin III is formed after a terminal aspartic acid amino acid group is cleaved by aminopeptidase A. Angiotensin III has decreased effect on blood pressure but maintains angiotensin II’s hormonal effects.
Mutations in this gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation and inflammatory bowel disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.