Thermo Fisher Scientific TRIM25 Monoclonal Antibody (5C3)
TRIM25 단백질을 인식하는 Mouse monoclonal antibody (Clone 5C3). Western blot, IHC, ICC/IF, ELISA에 사용 가능. Human 시료 반응성. Affinity chromatography로 정제된 액상 항체이며, PBS buffer에 보존. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 3 µg/mL |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5C3 |
| Immunogen | TRIM25 (NP_005073, 211–310 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
SQINGASRAL DDVRNRQQDV RMTANRKVEQ LQQEYTEMKA LLDASETTST RKIKEEEKRV NSKFDTIYQI LLKKKSEIQT LKEEIEQSLT KRDEFEFLEK
Target Information
TRIM25, also known as estrogen responsive finger protein (EFP), is a member of the RING finger-B box-coiled coil family and a downstream target of estrogen receptor α.
Mice lacking this gene show an underdeveloped uterus and reduced estrogen responsiveness, indicating its essential role in estrogen-dependent proliferation.
TRIM25 expression is increased in breast carcinoma, promoting tumor growth by functioning as an E3 ubiquitin ligase targeting the negative cell cycle checkpoint 14-3-3σ.
Recent studies show that TRIM25 E3 ubiquitin ligase activity is essential for the RIG-I signaling pathway in antiviral innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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