Thermo Fisher Scientific TPC2 Polyclonal Antibody
Rabbit polyclonal antibody targeting mouse TPC2 protein. Validated for WB and IHC applications. Lyophilized form, reconstitute in sterile water. For research use only. Recommended storage at -20°C for long term stability.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:1,000–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from a cytoplasmic domain of mouse TPC2 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: TPC2.
Target Information
Tpcn2 (Two-Pore Channel 2) is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca²⁺ channels across the lysosomal membrane. It may also be involved in smooth muscle contraction.
The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain structure. The Tpcn2 protein localizes to lysosomal membranes and mediates NAADP-induced calcium ion release from lysosome-related stores.
Tpcn2 is ubiquitously expressed, with higher levels in liver and kidney. Two nonsynonymous SNPs in the Tpcn2 gene are associated with hair pigmentation (blond vs. brown).
Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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