Thermo Fisher Scientific KIF14 Polyclonal Antibody
Rabbit polyclonal antibody targeting human KIF14 protein. Validated for IHC (paraffin) with high specificity. Supplied as liquid, unconjugated form with 0.30 mg/mL concentration. Suitable for research use in studying cell division and cancer-related pa...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human KIF14. Recombinant protein control fragment (Product #RP-94981). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.30 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2643084 |
Product Specific Information
Immunogen sequence:
KESRTNVRIV NNAKNSFVAS SVPLDEDPQV IEMMADKKYK ETFSAPSRAN ENVALKYSSN RPPIASLSQT EVV
- Highest antigen sequence identity to orthologs:
- Mouse: 30%
- Rat: 34%
Target Information
The KIF14 gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in processes such as vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis.
In human HeLa-S3 and 293T cells:
- Localized to the cytoplasm during interphase
- Localized to spindle poles and microtubules during mitosis
- Localized to the midbody during cytokinesis
The internal motor domain exhibits microtubule-dependent ATPase activity, consistent with its role as a motor protein. Knockdown of KIF14 can lead to failed cytokinesis and multinucleated cells. It has been identified as a potential oncogene in breast, lung, and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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