Thermo Fisher Scientific IL1F6 Monoclonal Antibody (OTI3A2)
IL1F6 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, ICC/IF, Flow Cytometry에 사용 가능. 인간 IL1F6에 특이적이며 액상 형태로 제공. 고순도 친화 크로마토그래피 정제, 안정적 PBS 기반 버퍼로 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A2 |
| Immunogen | Full length human recombinant protein of IL1F6 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724516 |
Target Information
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9).
IL-36α is highly expressed in psoriatic plaques, as are IL-36β and IL-36γ, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells.
Primarily found in skin and lymphoid tissues, IL-36α is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine.
IL-36α signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein).
IL-36α functions as an agonist of NF-kappaB and MAPK pathways, inducing production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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