Thermo Fisher Scientific SV40 Large T-Antigen Monoclonal Antibody (PAb101 (412))

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

-

Immunoprecipitation (IP)

Assay-dependent

-

In vitro Assay (IV)

-

- -

Product Specifications

Published species

Virus

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

PAb101 (412)

Immunogen

SV40 transformed mouse line B4

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10984065

Product Specific Information

This antibody reacts with native and denatured large T-antigen. It does not react with the small T-antigen of SV40 or the large T-antigen of BKV, human papovavirus.

Target Information

The SV40 T antigen is encoded by the early region of the SV40 genome. The large T antigen binds DNA, and complexes with a 53,000 dalton cellular protein, p53, which is required for initiation of viral DNA replication during lytic growth. In addition, the large T antigen binds DNA polymerase and the transcription factor AP-2 and forms a specific complex with the P105 product of the retinoblastoma susceptibility gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.