Thermo Fisher Scientific Sgt-1A Monoclonal Antibody (5B12F5)
인간 Sgt-1A 단백질을 인식하는 마우스 단클론 항체입니다. 면역조직화학(IHC) 분석에 적합하며, 핵 단백질 검출에 사용됩니다. 0.5 mg/mL 농도의 액상 형태로 제공되며, 단백질 A로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2–10 µg/mL
- Positive control: Testis
- Cellular location: Nucleus
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B12F5 |
| Immunogen | Recombinant protein Sgt A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. Human Sgt1 (Suppressor of the G2 allele of Skp1) has two isoforms: Sgt-1A and Sgt-1B. This protein interacts with heat shock protein 90. Sgt1 translocates to the nucleus upon heat shock, and the Ca(2+)-bound form of S100A6 is required for this translocation. S100A6-Ca(2+)-mediated Sgt1 dephosphorylation promotes nuclear translocation, likely due to disruption of the Sgt1-Hsp90 complex. SUGT1 (Sgt-1) protein expression has been observed in lung, testis, liver, and brain, and is overexpressed in human colorectal cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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