Thermo Fisher Scientific VPS51 Polyclonal Antibody
Human VPS51 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 포맷. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific VPS51 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human VPS51. Recombinant protein control fragment (Product #RP-97383) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649475 |
Product Specific Information
Immunogen sequence:
FDPEVYLDKL RRECPLAQLM DSETDMVRQI RALDSDMQTL VYENYNKFIS ATDTIRKMKN DFRKMEDEMD RLATNMAVIT DFS
Ortholog sequence identity:
- Mouse: 99%
- Rat: 99%
Target Information
VPS51 acts as a component of the GARP complex involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is essential for protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic, and autophagy.
VPS51 also participates in retrograde transport of acid hydrolase receptors by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.
Additionally, it acts as a component of the EARP complex involved in endocytic recycling, associating with Rab4-positive endosomes and promoting recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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