Thermo Fisher Scientific PSMA7 Polyclonal Antibody
PSMA7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human PSMA7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803891 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays essential roles by associating with different regulatory particles.
When associated with two 19S regulatory particles, forms the 26S proteasome and participates in ATP-dependent degradation of ubiquitinated proteins.
The 26S proteasome maintains protein homeostasis by removing misfolded or damaged proteins and proteins no longer required.
Associated with PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation, required in pathways such as spermatogenesis (20S-PA200 complex) or generation of MHC class I-presented antigenic peptides (20S-PA28 complex).
Inhibits HIF-1A transactivation under normoxic and hypoxic conditions. Interaction with EMAP2 increases proteasome-mediated HIF-1A degradation under hypoxia.
Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR), enhancing androgen-mediated transactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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